The Left Angle Cross of Cycles is named for Gate 53 and Gate 54, both seated in the Root. Human Design reads Gate 53, from Hexagram 53, Development, as the pressure to begin, an impulse that starts new cycles and often has no interest in seeing them through; and Gate 54, from Hexagram 54, The Marrying Maiden, as ambition, the drive to rise and transform one's material circumstances. It belongs to the Left Angle family, read as transpersonal, a direction practitioners describe as answering less to personal choice than to what circumstance hands the individual.
Its design half is Gate 42 and Gate 32. Gate 42 sits in the Sacral centre and is read as the energy to carry a process through to its natural end rather than abandoning it midway; it pairs with Gate 53 in the channel of Maturation. Gate 32 sits in the Spleen and is read as an instinct for what will last, and caution about change undertaken for its own sake; it pairs with Gate 54 in the channel of Transformation.
So a chart carrying this cross starts and rises on a shared Root surface, while beneath it a drive to finish answers to a caution about change for its own sake, the design gates each named after the very personality gates they complete. The same pair also underlies the Juxtaposition Cross of Beginnings and, reversed, the Juxtaposition Cross of Ambition. The hexagrams are ancient; grouping them into one transpersonal cross is the modern system's own construction, dated to 1987.