Galen inherited from the Hippocratic corpus the theory that health depends on the balance of four bodily humors, blood, phlegm, yellow bile and black bile, and he extended it into a full theory of temperament, arguing that the relative dominance of each humor in an individual produces a corresponding disposition, sanguine, phlegmatic, choleric or melancholic, that shapes not only susceptibility to disease but personality itself. This fusion of physiology and character reading gave Western medicine a working model of the person that lasted, essentially unchallenged, into the early modern period, and it fed directly into later systems, astrology among them, that mapped the four humors onto the four elements and the planets, treating bodily constitution and psychological type as two readings of the same underlying pattern.
Galen's medical corpus, running to hundreds of individual treatises, was translated into Syriac and Arabic within a few centuries of his death and became the backbone of medieval Islamic medicine under physicians such as al-Razi and Avicenna, who both extended and occasionally challenged him, before Latin translations carried the same authority into medieval and Renaissance European universities. Only with the sixteenth century anatomical work of Andreas Vesalius, which corrected numerous errors traceable to Galen's having dissected animals rather than human cadavers, did his authority in anatomy specifically begin to be displaced, though his broader humoral framework persisted in popular use well beyond that.