Human Design makes frequent use of genetic language, and the claim underneath it needs to be separated carefully from the metaphor built on top of it.
The arithmetic is real. The I Ching has sixty-four hexagrams because each is six lines with two possible states, and two to the sixth power is sixty-four. The genetic code has sixty-four codons because each is three bases drawn from an alphabet of four, and four cubed is sixty-four. Both numbers are sixty-four, and both arise from a short sequence over a small alphabet. That much is simply true and can be checked.
The inference is not established. Human Design treats the coincidence as evidence of a correspondence, mapping gates to codons and describing activated gates as genetic imprinting. There is no result in molecular biology supporting a mapping between hexagrams and codons, no mechanism by which planetary positions could select codons, and no peer-reviewed work testing the proposal. The correspondence is an analogy that the system finds illuminating, and it should be described as such.
Gate 41 carries a specific version of this. Human Design holds that it begins the cycle of all sixty-four, and describes it by analogy with a start codon, the triplet at which the reading of a gene begins. Within the system this gives Gate 41 a structural priority: it is where the round of human experience starts. In the I Ching, the forty-first hexagram is Decrease, and occupies no special position in the King Wen sequence at all.
So the start-of-cycle claim is Ra Uru Hu's, dating from 1987, and it is an architectural decision within his system rather than a fact about either the I Ching or genetics. Practitioners hold it; the entries here describe it without asserting it.