Acts tells the story of the road to Damascus three times, which is a measure of how much weight the book puts on it. Saul is travelling to the city with authority to arrest believers there, meaning a community already existed; he is blinded, led in, and lodged in a house on the street called Straight, where a disciple named Ananias is sent to him against his own better judgement. The Roman street survives as the long straight axis of the old city, and a small underground chapel near its eastern end is venerated as the house of Ananias. Paul's own account adds the detail that he left the city let down the wall in a basket, escaping an official of the Nabataean king Aretas rather than a Jewish crowd.
Damascus remains a patriarchal seat. The Greek Orthodox Patriarch of Antioch and All the East resides in the old city, and the Syriac Orthodox patriarchate moved its seat here in the twentieth century, so two of the successions that trace themselves to Antioch are administered from Damascus.
South of the city stands the shrine of Sayyida Zaynab, venerated by Twelver Shia as the burial place of the daughter of Ali and sister of Husayn, who was taken captive to Damascus after Karbala and is remembered for confronting the caliph in his own court. The shrine draws pilgrims from Iran, Iraq, Lebanon and the Gulf, and a Shia quarter has grown around it. A second shrine within the walls, that of Sayyida Ruqayya, commemorates a child of Husayn's household who died in captivity there.