Robert Gordon Wasson was born on 18 September 1898. He built a conventional career in finance, eventually becoming a vice president at the banking house J.P. Morgan and Co., while pursuing mushroom study as a serious amateur interest alongside his wife, the pediatrician Valentina Pavlovna Wasson, whose own Russian background had first sparked his curiosity about the sharply different attitudes toward fungi in different cultures. In 1955 the couple traveled to Huautla de Jimenez in Oaxaca, Mexico, where the Mazatec curandera Maria Sabina permitted Wasson to participate in and document a traditional veladas ceremony using psilocybin mushrooms.
Wasson's 1957 account of that ceremony, published in Life magazine, was the first widely read description of a psilocybin mushroom ceremony for a general Western audience and is credited with substantially shaping later popular and scientific interest in entheogens. He went on to found ethnomycology, the systematic study of the relationship between fungi and human culture and religion, as a recognized field, publishing extensively until his death on 23 December 1986.
His Life magazine account, titled Seeking the Magic Mushroom, ran in the magazine's May 1957 issue and reached an audience of millions, a scale of exposure no earlier academic account of entheogenic plant use had approached; it is widely credited with drawing the American counterculture's later attention toward psilocybin mushrooms years before their active chemical compound was synthesized and studied clinically. Wasson insisted throughout his career that his interest was scholarly and comparative rather than an endorsement of recreational use, a distinction he maintained explicitly in his later, more academic publications.